Sains Malaysiana 49(3)(2020): 653-660

http://dx.doi.org/10.17576/jsm-2020-4903-20

The Effect of Different Concentrations of Calcium Silicate-Maghemite Coating towards Magnetic Behavior and Bioactivity

(Kesan Kepekatan Berbeza Salutan Kalsium Silikat-Magemit kepada Tingkah Laku Magnet dan Aktiviti Bionya)

NOR HAZIRAH MOHD AKHIRUDIN, ROSLINDA SHAMSUDIN & NORINSAN KAMIL OTHMAN*

School of Applied Physics, Faculty of Science and Technology, Universiti Kebangsaan Malaysia, 43600 UKM Bangi, Selangor Darul Ehsan, Malaysia

Diserahkan: 10 September 2019/Diterima: 5 Disember 2019

ABSTRACT

In this study, maghemite (γ-Fe₂O₃) as magnetic nanoparticles (MNPs) material was coated by ceramic materials, calcium silicate (CaSiO₃) with different concentrations to suit the medical treatment needed. Different concentration was studied to assess the optimal parameter and ability to maintain post-coated superparamagnetic properties of γ-Fe₂O₃.  Concentration of CaSiO₃ coated on γ-Fe₂O₃ was prepared with 3 parameters, 97:3, 95:5, and 93:7% w/w, respectively. Magnetic properties of CaSiO₃-γ-Fe₂O₃ were characterized by VSM proceeded with a bioactive study analyzed with FESEM and FTIR after simulated body fluid immersion for 5 days at 37±1ºC. CaSiO₃-γ-Fe₂O₃ with concentration 95:5% w/w exhibit the highest magnetization makes it the most optimum with the average coercivity is 1.6G. FESEM analysis illustrates that the existence of the apatite layer after 5 days of simulated body fluid (SBF) immersion on CaSiO₃-γ-Fe₂O₃ coating sample, which confirmed the bioactive properties. Therefore, CaSiO₃-γ-Fe₂O₃ concentration at ratio 95:5% w/w can be a promising new biomaterial candidate to be applied in the medical field.

Keywords: Bioactive; calcium silicate coating; maghemite; superparamagnetic

ABSTRAK

Dalam kajian ini, magemit (γ-Fe₂O₃) sebagai bahan nanozarah magnetik (MNPs) disalut oleh bahan seramik iaitu kalsium silikat (CaSiO₃) dengan kepekatan yang berbeza untuk memenuhi keperluan rawatan perubatan. Kepekatan yang berbeza dikaji untuk menentukan parameter yang ideal dan keupayaan untuk mengekalkan sifat superparamagnetik yang dimiliki oleh γ-Fe₂O₃ selepas proses salutan. Kepekatan CaSiO₃ menyalut kepada γ-Fe₂O₃ disediakan dengan 3 parameter yang berbeza, 97:3% w/w, 95:5% w/w dan 93:7% w/w. Sifat magnetik CaSiO₃-γ-Fe₂O₃ dicirikan oleh VSM kemudiannya diteruskan dengan kajian sifat bioaktif yang dianalisis menggunakan FESEM dan FTIR selepas direndamkan ke dalam larutan simulasi badan (SBF) selama hari pada 37 ± 1ºC. CaSiO₃-γ-Fe₂O₃ dengan kepekatan 95:5% w/w menunjukkan nilai magnetisasi tertinggi menjadikannya parameter paling optimum dengan purata koersiviti ialah 1.6G. Analisis FESEM menunjukkan kehadiran lapisan apatit selepas 5 hari rendaman SBF pada sampel CaSiO₃-γ-Fe₂O₃ mengesahkan sifat bioaktif yang dimiliki. Oleh itu, kepekatan CaSiO₃-γ-Fe₂O₃ pada nisbah 95:5% w/w mempunyai potensi untuk dijadikan calon biobahan yang baru untuk diaplikasikan dalam bidang perubatan.

Kata kunci: Bioaktif; magemit; salutan kalsium silikat; superparamagnetik

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*Pengarang untuk surat-menyurat; email: insan@ukm.edu.my