Sains Malaysiana 50(12)(2021): 3537-3545

http://doi.org/10.17576/jsm-2021-5012-06

 

Effects of Traditional and Convenient Edible Bird's Nest on Spatial Learning of

Male Sprague-Dawley Rats

(Kesan Sarang Burung Tradisi dan Mudah-Masak ke atas Pembelajaran Reruang Tikus Sprague-Dawley Jantan)

 

HAZIQ KAMAL1, KHIDHIR KAMIL1, NELSON TAN KAR WAI1, ABDUL LATIF NOOR BIN AMIRUDDIN1, MANMEET KAUR PRITHVIRAJ SINGH1, NURUL AINA BINTI JOHANIFF1, NURSYAHIRAH BINTI ABDUL HALIM1, AZMAWATI MOHAMMED NAWI2, CHUA KIEN HUI1 & JAYA KUMAR1*

 

1Department of Physiology, Faculty of Medicine, Universiti Kebangsaan Malaysia Medical Centre, 56000 Cheras, Kuala Lumpur, Federal Territory, Malaysia

 

2Department of Community Health, Faculty of Medicine, Universiti Kebangsaan Malaysia Medical Centre, 56000 Cheras, Kuala Lumpur, Federal Territory, Malaysia

 

Diserahkan: 23 April 2020/Diterima: 13 April 2021

 

ABSTRACT

Consumption of edible bird's nest (EBN) has been a common practice for the health benefits it is believed to provide. Hence, this study aimed to investigate the effects of both traditional edible bird's nest (TEBN) and convenient edible bird’s nest (CEBN) on the spatial learning of male Sprague Dawley rats in a radial arm maze (RAM). A total of 24 male rats (270-300 g) were allocated into three groups based on diet given namely pellet only (control group), pellet mixed with TEBN (300 mg/kg) and pellet mixed with CEBN (300 mg/kg). The rats were fed with the aforementioned diet throughout the study for 42 days and exposed to RAM for spatial learning assessments which consisted of shaping (3 days), acquisition (8 days) and retention (1 day) trials. In the acquisition trials, CEBN reduced working memory error (WME) on day 5 compared to control, and day 6 compared to the TEBN group. TEBN markedly reduced reference memory error (RME) on day 1 and 8, time spent (day 3) and percentage of correct choices made (day 3) during the acquisition trials compared to CEBN. TEBN and CEBN significantly reduced WME, however, only CEBN increased RME during the retention trial. CEBN significantly affected the total entries produced in the RAM which indicated the non-specific effects of CEBN on the locomotion of the rats. Our findings suggested that TEBN may work better than CEBN in improving spatial learning considering the fact that CEBN markedly reduced the locomotion of the rats during the retention trial.

 

Keywords: Cognition; radial arm maze; spatial memory; supplement; working memory

 

ABSTRAK

Pengambilansarang burung Walit’ (EBN) telah menjadi amalan biasa oleh kerana ia dipercayai mempunyai manfaat kesihatan. Oleh itu, kajian ini bertujuan mengkaji kesansarang burung Walit tradisi (TEBN) dan ‘sarang burung Walit mudah-masak’ (CEBN) ke atas pembelajaran reruang tikus Sprague Dawley jantan dalam lorongan keliru lengan radial (RAM). Sebanyak 24 ekor tikus jantan (270-300 g) telah dibahagikan kepada tiga kumpulan berdasarkan diet yang diberikan iaitu pelet sahaja (kumpulan kawalan), pelet yang dicampurkan dengan TEBN (300 mg/kg) dan pelet yang dicampurkan dengan CEBN (300 mg/kg). Kesemua tikus telah diberi diet tersebut sepanjang kajian selama 42 hari dan didedahkan kepada RAM untuk penilaian pembelajaran reruang yang terdiri daripada percubaan pembentukan (3 hari), perolehan (8 hari) dan pengekalan (1 hari). Dalam percubaan perolehan, CEBN telah mengurangkan ralat ingatan kerja (WME) pada hari ke-5 berbanding kawalan dan hari ke-6 berbanding kumpulan TEBN. TEBN telah mengurangkan ralat ingatan rujukan (RME) dengan ketara pada hari pertama dan ke-8, masa yang diambil (hari ke-3) dan peratusan membuat pilihan yang betul (hari ke-3) semasa percubaan perolehan berbanding CEBN. TEBN dan CEBN telah mengurangkan WME secara signifikan, namun hanya CEBN yang meningkatkan RME semasa percubaan pengekalan. CEBN mempengaruhi keseluruhan entri yang dihasilkan dalam RAM secara signifikan yang menunjukkan kesan tidak khusus CEBN pada pergerakan tikus. Penemuan ini mencadangkan TEBN mungkin berfungsi lebih baik daripada CEBN dalam meningkatkan pembelajaran reruang memandangkan CEBN telah mengurangkan pergerakan tikus secara signifikan semasa percubaan pengekalan.

 

Kata kunci: Ingatan kerja; ingatan reruang; kognisi; lorongan keliru lengan radial; suplemen

 

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*Pengarang untuk surat-menyurat; email: jayakumar@ukm.edu.my

 

   

   

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