Sains
Malaysiana 50(12)(2021): 3683-3691
http://doi.org/10.17576/jsm-2021-5012-18
A Randomized
Controlled Trial on the Effect of VCO in Reducing Glucose and Body Weight in
Post-Acute Coronary Syndrome Patients: A Pilot Study
(Ujian
Terkawal Rawak terhadap Kesan VCO dalam Mengurangkan Glukosa dan Berat Badan
pada Pesakit Sindrom Koronari Pascaakut: Suatu Kajian Perintis)
SHARIFAH SHAFINAZ BINTI SH ABDULLAH1,2,
MEI CHAN CHONG1*, KHATIJAH LIM ABDULLAH2, IMRAN ZAINAL
ABIDIN3 & BEE WAH YAP4
1Nursing
Department, Faculty of Medicine, University of Malaya, Jalan Universiti, 50603
Kuala Lumpur, Wilayah Persekutuan, Malaysia
2Department of Nursing,
School of Medical and Life Sciences,
Sunway University, Jalan Universiti,
Bandar Sunway,
47500 Petaling Jaya, Selangor Darul Ehsan,
Malaysia
3Medical
Department, Faculty of Medicine, University of Malaya, Jalan Universiti, 50603
Kuala Lumpur, Wilayah Persekutuan, Malaysia
4Faculty
of Computer and Mathematical Sciences, Universiti Teknologi MARA, 40450 Shah
Alam, Selangor Darul Ehsan, Malaysia
Diserahkan:
1 Mei 2020/Diterima: 24 Mac 2021
ABSTRACT
The
aims of this paper were to determine the effect of virgin coconut oil (VCO) on
bodyweight and serum glucose level among acute coronary syndrome (ACS)
patients. Various clinical trials on animal studies have found that the VCO has
many beneficial effects on health. However, there have been limited published
human studies on the pharmacological properties of VCO. Investigation on human
subjects is extremely required in order to provide more empirical evidence to
show the effect of VCO for ACS patients. Randomised single blind study
conducted between March 2018 and April 2018. RCT was conducted among 70 ACS
patients for 30 days. Participants in group A received their bottles containing
100 pieces of virgin coconut oil soft gels and were required to ingest 10
capsules per day (5 mL/5 gm) and continue routine treatment (diabetic diet and
diabetic medication). Group B participants continued receiving routine
treatment. Changes in serum fating blood sugar and body weight were identified
using a paired t-test and independent t-test. A total of 70 patients
participated with ages of 51 years old and older and were mostly male. The
serum FBS and body weight of the intervention group that received VCO were
reduced about 13.6% on day 30, from the baseline on day 1. They also had body
weight reduction of about 2% with p value of less than 0.05. In contrast, the
control group that only received routine treatment showed an increment of 12.1%
in their serum FBS and had no changes in body weight. These reductions were
noted within 30 days of consuming a daily dose of VCO (5 g every day). The
properties of lauric acid and antioxidants present in the VCO composition were
key players in the reduction of serum glucose levels and body weight. VCO can
reduce serum glucose levels and body weight with 5 mL (5 g) of VCO per day for
30 days. Also, VCO may have a positive effect towards the glucose level and
other cardiovascular risk factors.
Keywords:
Acute coronary syndrome; diabetes mellitus; medium chain triglyceride; virgin
coconut oil
ABSTRAK
Kajian
ini bertujuan untuk melihat keberkesanan minyak kelapa dara ke atas serum
glukosa dan berat badan dalam kalangan pesakit sindrom koronari akut (SKA).
Kajian ke atas haiwan mendapati minyak kelapa dara mempunyai beberapa kesan
kepada kesihatan. Walau bagaimanapun, kajian keberkesanan minyak kelapa dara ke
atas manusia adalah terhad. Penyelidikan keberkesanan minyak kelapa dara
terhadap manusia adalah diperlukan untuk menyediakan lebih bukti empirik
terhadap kesan minyak kelapa dara kepada pesakit SKA. Ujian terkawal rawak buta
tunggal telah dijalankan pada Mac 2018 sehingga April 2018. RCT telah
dijalankan ke atas 70 orang pesakit SKA selama 30 hari. Peserta daripada kumpulan A
telah diberi satu botol yang mengandungi 100 biji kapsul minyak kelapa dara dan
perlu mengambil 10 kapsul sehari (5 mL/5 gm) serta meneruskan rutin perawatan
(diet dan ubat diabetik). Peserta daripada kumpulan B pula meneruskan rutin
perawatan seperti biasa. Perubahan pada serum glukosa dan berat badan dikenal
pasti dengan menggunakan analisis ujian t berpasangan dan ujian t tak bersandar.
Seramai 70 peserta kajian kebanyakannya terdiri daripada peserta lelaki dan
berusia dalam lingkungan 51 tahun dan lebih. Perbandingan serum glukosa daripada
kumpulan intervensi menampakkan penurunan dari hari pertama kajian sehingga
hari ke 30 sebanyak 13.6% dan penurunan berat badan adalah sebanyak 2%, dengan
kadar signifikasi kurang daripada 0.05. Kumpulan yang menerima penjagaan rutin
menunjukkan peningkatan serum FBS sebanyak 12.1% dan tiada perubahan dalam
berat badan. Penurunan ini dapat dilihat pada hari ke 30 dengan pengambilan VCO
sebanyak 5 g sehari. Kesan penurunan glukosa dan berat badan adalah disebabkan
oleh tindakan asid laurik dan antioksida yang terdapat di dalam komposisi VCO.
Minyak kelapa dara menunjukkan keupayaan menurunkan serum glukosa dan berat
badan dengan dos 5 mL/5 gm sehari selama 30 hari. Minyak kelapa dara mempunyai
kesan positif terhadap serum glukosa dan faktor risiko kardiovaskular yang
lain.
Kata
kunci: Diabetes mellitus; minyak kelapa dara; sindrom koronari akut;
trigliserida rantai sederhana
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*Pengarang untuk surat-menyurat;
email: mcchong@um.edu.my
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